There are some genetic conditions caused by having more or less than 2 sex chromosomes.
45,X (Turner syndrome)
47,XXX (Trisomy X)
47,XXY (Klinefelter syndrome)
48,XXXX (Tetrasomy X)
48,XXXY (XXXY syndrome)
49,XXXXX (Pentasomy X)
49,XXXXY (XXXXY syndrome)
Man to become the first male ever to receive a hysterectomy
Persistent Müllerian duct syndrome (PMDS)
XY complete gonadal dysgenesis (also known as Swyer syndrome)